{"id":10315,"date":"2023-02-01T12:17:18","date_gmt":"2023-02-01T11:17:18","guid":{"rendered":"https:\/\/www.amirasrl.com\/distribuzione-ciclo-h2o2\/"},"modified":"2023-03-14T12:10:12","modified_gmt":"2023-03-14T11:10:12","slug":"h2o2-cycle-distribution","status":"publish","type":"post","link":"https:\/\/www.amirasrl.com\/en\/h2o2-cycle-distribution\/","title":{"rendered":"Distribution challenge in H2O2 bio-decontamination cycle"},"content":{"rendered":"<p>Regardless of the application, the size of the enclosure or the environment conditions, every H<sub>2<\/sub>O<sub>2 <\/sub>bio-decontamination cycle must deal with a geometrical problem.<\/p>\n<p>In fact, the decontamination agent is always released into the area somewhere in the space, but it must reach every corner of the enclosure to be treated for a successful H<sub>2<\/sub>O<sub>2 <\/sub>bio-decontamination cycle.<\/p>\n<p>This is a well-known challenge for those who want to perform fast cycles in complex spaces. A clarification may be useful at this point.<\/p>\n<p><br class=\"avia-permanent-lb\">In any H<sub>2<\/sub>O<sub>2 <\/sub>bio-decontamination cycle there may be two different limitations linked with agent distribution:<\/p>\n<ul>\n<li>diffusion limit<\/li>\n<li>time limit<\/li>\n<\/ul>\n<h3><strong> <br class=\"avia-permanent-lb\">Diffusion limit<\/strong><\/h3>\n<p>The inability to reach a specific point of the area is linked with the spread capability of the decontamination agent. Good examples may be:<\/p>\n<ul>\n<li>the shadow effect behind physical objects in sprayed H<sub>2<\/sub>O<sub>2<\/sub> decontamination method<\/li>\n<li>a door closed that does not allow the distribution in a specific area.<\/li>\n<\/ul>\n<p>In both cases, longer exposure would not help, as the agent will never get to that specific point. The problem may be solved only through different positioning of objects and space configuration.<\/p>\n<h3><strong> <br class=\"avia-permanent-lb\">Time limit<\/strong><\/h3>\n<p>The decontamination agent is actually able to reach every point of the area, but it may take longer time than expected to get a certain result on a specific spot. In this case repositioning of objects may help, but the issue can be solved easily with a longer cycle time. A good example is H<sub>2<\/sub>O<sub>2<\/sub> vapor decontamination method (V-PHP), where the gas can reach every point of the space in time, but longer time may be required in case of big areas or complex spaces.<\/p>\n<p><br class=\"avia-permanent-lb\">Demonstrating a proper distribution of the sporicidal in RABS application is one of the requirements of <a href=\"https:\/\/health.ec.europa.eu\/latest-updates\/revision-manufacture-sterile-medicinal-products-2022-08-25_en\" target=\"_blank\" rel=\"noopener\">New Annex 1<\/a>.<\/p>\n<p><br class=\"avia-permanent-lb\">If you would like to get support in performing a specific risk assessment to identify potential critical issues and define right cycle settings, <a href=\"https:\/\/www.amirasrl.com\/en\/contact\/\" target=\"_blank\" rel=\"noopener\">contact us<\/a> to talk with our V-PHP biodecontamination specialists.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Regardless of the application, the size of the enclosure or the environment conditions, every H2O2 bio-decontamination cycle must deal with a geometrical problem. In fact, the decontamination agent is always released into the area somewhere in the space, but it must reach every corner of the enclosure to be treated for a successful H2O2 bio-decontamination [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":10308,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[32],"tags":[],"class_list":["post-10315","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-technology-insight"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Distribution challenge in H2O2 bio-decontamination cycle - Amira srl<\/title>\n<meta name=\"description\" content=\"H2O2 bio-decontamination cycle: risk assessment to identify potential critical issues and define right cycle settings\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.amirasrl.com\/en\/h2o2-cycle-distribution\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Distribution challenge in H2O2 bio-decontamination cycle - 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